Non-nutritive sweeteners back in the spotlight as new study challenges notion they are inert and says they can impact glycemic tolerance

A new study â published a month after the World Health Organization (WHO) sounded a cautionary note about the long-term effects of zero-calorie sweeteners such as sucralose and saccharin â suggests some diet sweeteners are not inert and can alter the microbiome in a way that may impact glycemic tolerance, claims that were immediately challenged by industry stakeholders.

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